Dataset Information

The Paired Orphan Immune Receptors LILRA6 and LILRB3 Modulate Fc Receptor Mediated Functions of Neutrophils

ABSTRACT: to characterise expression of LILRA6/LILRB3 receptors during neutrophil differentiation and activation, and to characterise their roles in modulating Fc receptor mediated effector functions.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neutrophil, Blood

SUBMITTER: Jing Zhu

LAB HEAD: Albert J.R. Heck

PROVIDER: PXD015561 | Pride | 2020-11-04

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20190910_OR14_Ag2_Zhu00015_SA_D1_IP_A6.raw	Raw
	20190910_OR14_Ag2_Zhu00015_SA_D1_IP_B3.raw	Raw
	20190910_OR14_Ag2_Zhu00015_SA_D1_IP_G1.raw	Raw
	20190910_OR14_Ag2_Zhu00015_SA_D1_IP_G2A.raw	Raw
	20190910_OR14_Ag2_Zhu00015_SA_D2_IP_A6.raw	Raw

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Publications

The Orphan Immune Receptor LILRB3 Modulates Fc Receptor-Mediated Functions of Neutrophils.

Zhao Yuxi Y van Woudenbergh Esther E Zhu Jing J Heck Albert J R AJR van Kessel Kok P M KPM de Haas Carla J C CJC Aerts Piet C PC van Strijp Jos A G JAG McCarthy Alex J AJ

Journal of immunology (Baltimore, Md. : 1950) 20200108 4

Neutrophils are critical to the generation of effective immune responses and for killing invading microbes. Paired immune receptors provide important mechanisms to modulate neutrophil activation thresholds and effector functions. Expression of the leukocyte Ig-like receptor (LILR)A6 (ILT8/CD85b) and LILRB3 (ILT5/CD85a) paired-receptor system on human neutrophils has remained unclear because of the lack of specific molecular tools. Additionally, there is little known of their possible functions i ...[more]

PMID: 31915259

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