Proteomics

Dataset Information

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Proteomic Analysis of Myotube-Secreted Exosomes of Amyotrophic Lateral Sclerosis (ALS) and Healthy subjects


ABSTRACT: In order to investigate a potential role of muscle exosomes in the pathology of Amyotrophic Lateral Sclerosis (ALS), we undertook a proteomic study of the content of exosomes secreted by myotubes of ALS and Healthy subjects.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Myotube

DISEASE(S): Amyotrophic Lateral Sclerosis

SUBMITTER: William Duddy  

LAB HEAD: Stephanie Duguez

PROVIDER: PXD015736 | Pride | 2021-03-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Dugez-Exo-SG-ALS1-SD990-01.raw Raw
Dugez-Exo-SG-ALS1-SD990-02.raw Raw
Dugez-Exo-SG-ALS1-SD990-03.raw Raw
Dugez-Exo-SG-ALS1-SD990-04.raw Raw
Dugez-Exo-SG-ALS1-SD990-05.raw Raw
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Publications

Optimized method for extraction of exosomes from human primary muscle cells.

Le Gall Laura L   Ouandaogo Zamalou Gisele ZG   Anakor Ekene E   Connolly Owen O   Butler Browne Gillian G   Laine Jeanne J   Duddy William W   Duguez Stephanie S  

Skeletal muscle 20200708 1


Skeletal muscle is increasingly considered an endocrine organ secreting myokines and extracellular vesicles (exosomes and microvesicles), which can affect physiological changes with an impact on different pathological conditions, including regenerative processes, aging, and myopathies. Primary human myoblasts are an essential tool to study the muscle vesicle secretome. Since their differentiation in conditioned media does not induce any signs of cell death or cell stress, artefactual effects fro  ...[more]

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