Name: Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity
Keywords: Hdac3

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Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

ABSTRACT: Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Intestinal Epithelium, Small Intestine

SUBMITTER: Suresh Mathivanan

LAB HEAD: Prof John Mariadason

PROVIDER: PXD015738 | Pride | 2020-01-13

REPOSITORIES: Pride

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Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.

Dávalos-Salas Mercedes M Montgomery Magdalene K MK Reehorst Camilla M CM Nightingale Rebecca R Ng Irvin I Anderton Holly H Al-Obaidi Sheren S Lesmana Analia A Scott Cameron M CM Ioannidis Paul P Kalra Hina H Keerthikumar Shivakumar S Tögel Lars L Rigopoulos Angela A Gong Sylvia J SJ Williams David S DS Yoganantharaja Prusoth P Bell-Anderson Kim K Mathivanan Suresh S Gibert Yann Y Hiebert Scott S Scott Andrew M AM Watt Matthew J MJ Mariadason John M JM

Nature communications 20191122 1

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium is unknown. Here we demonstrate that intestine-specific deletion of Hdac3 (Hdac3<sup>IKO</sup>) protects mice from diet induced obesity. Intestinal epithelial cells (IECs) from Hdac3<sup>IKO</sup> mice display co-ordinate induction of genes and proteins involved in mitochondrial and peroxisomal β-oxidation, have an incr ...[more]

PMID: 31757939

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