Proteomics

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Genome-centric resolution of novel microbial lineages in a Centrosaurus fossil bone from the Late Cretaceous of North America

ABSTRACT: Exceptional preservation of endogenous organics such as collagens and osteocytes has been frequently reported in Mesozoic dinosaur fossils. The persistence of soft tissue in Mesozoic fossil bones has been challenged because of the susceptibility of proteins to degradation and because bone porosity allows microorganisms to colonize the inner microenvironments through geological time. Although protein lability has been studied extensively, the genomic diversity of microbiomes in dinosaur fossil bones and their potential roles in bone diagenesis remain underexplored. Genome-resolved metagenomics and metaproteomics were performed, therefore, on the microbiomes recovered from a Late Cretaceous Centrosaurus bone and its encompassing mudstone that were aseptically excavated in Dinosaur Provincial Park, Alberta, Canada, in order to provide insight into the genomic potential for bone alteration.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Betaproteobacteria Bacterium Rifcsplowo2_02_64_14 Deltaproteobacteria Bacterium Rifcsplowo2_12_full_50_11 Euzebya Tangerina

SUBMITTER: Renxing Liang  

LAB HEAD: Tullis Onstott

PROVIDER: PXD015750 | Pride | 2020-05-27

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
04272018_Onstott_RL_2911Mudstone_Lumos.raw Raw
04272018_Onstott_RL_291_1Bone_Lumos.raw Raw
09102017_Onstott_RL_174_1BEDTA_Lumos1.raw Raw
09102017_Onstott_RL_174_1M10g_Lumos1.raw Raw
10072017_Onstott_RL_190_Bone_Lumos1_SDB.raw Raw
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Publications

Interleukin-10 control of pre-miR155 maturation involves CELF2.

Yoon Jeff S J JSJ   Wu Mike K MK   Zhu Tian Hao TH   Zhao Helen H   Cheung Sylvia T ST   Chamberlain Thomas C TC   Mui Alice L-F AL  

PloS one 20200423 4

The anti-inflammatory cytokine interleukin-10 (IL10) is essential for attenuating inflammatory responses, which includes reducing the expression of pro-inflammatory microRNA-155 (miR155) in lipopolysaccharide (LPS) activated macrophages. miR155 enhances the expression of pro-inflammatory cytokines such as TNFα and suppresses expression of anti-inflammatory molecules such as SHIP1 and SOCS1. We previously found that IL10 interfered with the maturation of pre-miR155 to miR155. To understand the me  ...[more]

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