Proteomics

Dataset Information

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Proteome analysis of skeletal muscle samples from a porcine model of Duchenne muscular dystrophy

ABSTRACT: Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and characterized by massive structural and functional changes of skeletal muscle tissue, leading to terminal muscle failure. In this project, proteomics data from skeletal muscle of a genetically engineered DMD pig model were investigated in order to confirm muscular fibrosis and MSOT signals.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Skeletal Muscle

DISEASE(S): Duchenne Muscular Dystrophy

SUBMITTER: Florian Flenkenthaler  

LAB HEAD: Dr. Thomas Fröhlich

PROVIDER: PXD016003 | Pride | 2020-01-09

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
DMD-24d-6755-OA-R-wk4-upper-arm-2.raw Raw
DMD-24d-6755-OS-R-wk4-thigh-2.raw Raw
DMD-26d-6711-OA-R-wk4-upper-arm-1.raw Raw
DMD-26d-6711-OS-R-wk4-thigh-1.raw Raw
DMD-6d-6744-OA-R-wk1-upper-arm-1.raw Raw
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Publications

Biomarkers for monitoring of disease progression and response to therapy are lacking for muscle diseases such as Duchenne muscular dystrophy. Noninvasive in vivo molecular imaging with multispectral optoacoustic tomography (MSOT) uses pulsed laser light to induce acoustic pressure waves, enabling the visualization of endogenous chromophores. Here we describe an application of MSOT, in which illumination in the near- and extended near-infrared ranges from 680-1,100 nm enables the visualization an  ...[more]

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