Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)
TISSUE(S): Heart, Skeletal Muscle
DISEASE(S): Duchenne Muscular Dystrophy
SUBMITTER: Thomas Fröhlich
LAB HEAD: Thomas Fröhlich
PROVIDER: PXD027772 | Pride | 2021-12-01
REPOSITORIES: Pride
Action | DRS | |||
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Myocardium_peptides.txt | Txt | |||
Myocardium_proteinGroups.txt | Txt | |||
SKM_DMD_Middle_7060.raw | Raw | |||
SKM_DMD_Middle_7061.raw | Raw | |||
SKM_DMD_Middle_7066.raw | Raw |
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Disease models & mechanisms 20211216 12
Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathological hallmarks of DMD, but die before sexual maturity and cannot be propagated by breeding. Therefore, we generated female DMD+/- carriers. A single founder animal had 11 litters with 29 DMDY/-, 34 DMD+/- as well as 36 male and 29 female wild-type offspring. Bree ...[more]