Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: Jiagui Song
LAB HEAD: Hongquan Zhang
PROVIDER: PXD016008 | Pride | 2019-12-16
REPOSITORIES: pride
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Song Jiagui J Wang Tianzhuo T Chi Xiaochun X Wei Xiaofan X Xu Sidi S Yu Miao M He Huiying H Ma Ji J Li Xueying X Du Juan J Sun Xiaoran X Wang Yunling Y Zhan Jun J Zhang Hongquan H
Cell reports 20191201 11
The Hippo signaling pathway plays a key role in development and cancer progression. However, molecules that intrinsically inhibit this pathway are less well known. Here, we report that the focal adhesion molecule Kindlin-2 inhibits Hippo signaling by interacting with and degrading MOB1 and promoting the interaction between MOB1 and the E3 ligase praja2. Kindlin-2 thus inhibits the phosphorylation of LATS1 and YAP and promotes YAP translocation into the nucleus, where it activates downstream Hipp ...[more]