Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Multiple Myeloma
SUBMITTER: Jiefei Tong
LAB HEAD: Mike Moran
PROVIDER: PXD016020 | Pride | 2019-12-16
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Biyin-MG1321st.raw | Raw | |||
Biyin-MG1322nd.raw | Raw | |||
Biyin-MG1323rd.raw | Raw | |||
Biyin-MafB1st.raw | Raw | |||
Biyin-MafB2nd.raw | Raw |
Items per page: 1 - 5 of 10 |
The Journal of biological chemistry 20191210 7
The Maf proteins, including c-Maf, MafA, and MafB, are critical transcription factors in myelomagenesis. Previous studies demonstrated that Maf proteins are processed by the ubiquitin-proteasome pathway, but the mechanisms remain elusive. This study applied MS to identify MafB ubiquitination-associated proteins and found that the ubiquitin-specific protease USP7 was present in the MafB interactome. Moreover, USP7 also interacted with c-Maf and MafA and blocked their polyubiquitination and degrad ...[more]