Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio)
TISSUE(S): Heart
SUBMITTER: Johannes Graumann
LAB HEAD: Didier Y. R. Stainier
PROVIDER: PXD016235 | Pride | 2020-07-13
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 65 |
Fukuda Ryuichi R Marín-Juez Rubén R El-Sammak Hadil H Beisaw Arica A Ramadass Radhan R Kuenne Carsten C Guenther Stefan S Konzer Anne A Bhagwat Aditya M AM Graumann Johannes J Stainier Didier Yr DY
EMBO reports 20200709 8
Cardiac metabolism plays a crucial role in producing sufficient energy to sustain cardiac function. However, the role of metabolism in different aspects of cardiomyocyte regeneration remains unclear. Working with the adult zebrafish heart regeneration model, we first find an increase in the levels of mRNAs encoding enzymes regulating glucose and pyruvate metabolism, including pyruvate kinase M1/2 (Pkm) and pyruvate dehydrogenase kinases (Pdks), especially in tissues bordering the damaged area. W ...[more]