Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Amanda Miquilini Cordibello
LAB HEAD: Emer Suavinho Ferro
PROVIDER: PXD016265 | Pride | 2020-02-24
REPOSITORIES: Pride
Action | DRS | |||
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170711PESSAM02977_May1.mzid.gz | Mzid | |||
170711PESSAM02977_May1.raw | Raw | |||
170711PESSAM02977_May1.temp.mgf | Mgf | |||
170711PESSAM02977_May1.temp.pride.mgf.gz | Mgf | |||
170711PESSAM02978_May2.mzid.gz | Mzid |
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Biomolecules 20200217 2
Thimet oligopeptidase (EC 3.4.24.15; EP24.15; THOP1) is a potential therapeutic target, as it plays key biological functions in processing biologically functional peptides. The structural conformation of THOP1 provides a unique restriction regarding substrate size, in that it only hydrolyzes peptides (optimally, those ranging from eight to 12 amino acids) and not proteins. The proteasome activity of hydrolyzing proteins releases a large number of intracellular peptides, providing THOP1 substrate ...[more]