Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio) Mus Musculus (mouse)
TISSUE(S): Cell Culture, Fibroblast
SUBMITTER: David Stroud
LAB HEAD: David Stroud
PROVIDER: PXD016718 | Pride | 2020-03-18
REPOSITORIES: Pride
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191122_Boris_BR-134_MEF.zip | Other | |||
191122_Boris_BR-134_MEF_1.raw | Raw | |||
191122_Boris_BR-134_MEF_2.raw | Raw | |||
191122_Boris_BR-134_MEF_3.raw | Raw | |||
191122_Boris_BR-134_MEF_4.raw | Raw |
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Nature communications 20200311 1
The emergence of small open reading frame (sORF)-encoded peptides (SEPs) is rapidly expanding the known proteome at the lower end of the size distribution. Here, we show that the mitochondrial proteome, particularly the respiratory chain, is enriched for small proteins. Using a prediction and validation pipeline for SEPs, we report the discovery of 16 endogenous nuclear encoded, mitochondrial-localized SEPs (mito-SEPs). Through functional prediction, proteomics, metabolomics and metabolic flux m ...[more]