Proteomics

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Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factors of vaccine-enhanced disease


ABSTRACT: Vaccine-enhanced disease (VED) occurs as a result of vaccination followed by infection with virulent Mycoplasma pneumoniae. To date, VED has prevented development of an efficacious vaccine against this significant human respiratory pathogen. Herein we report that vaccination with M. pneumoniae lipid-associated membrane proteins (LAMPs) induces lung lesions consistent with exacerbated disease following challenge, without reducing bacterial loads. Removal of lipid moieties from LAMPs prior to vaccination eliminates VED and reduces bacterial loads after infection. Collectively, these data indicate that lipid moieties of lipoproteins are the causative factors of M. pneumoniae VED.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mycoplasma Pneumoniae 19294

SUBMITTER: Jeremy Balsbaugh  

LAB HEAD: Jeremy Balsbaugh

PROVIDER: PXD016814 | Pride | 2020-04-09

REPOSITORIES: Pride

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Lipid moieties of <i>Mycoplasma pneumoniae</i> lipoproteins are the causative factor of vaccine-enhanced disease.

Mara Arlind B AB   Gavitt Tyler D TD   Tulman Edan R ER   Geary Steven J SJ   Szczepanek Steven M SM  

NPJ vaccines 20200408 1


Vaccine-enhanced disease (VED) occurs as a result of vaccination followed by infection with virulent <i>Mycoplasma pneumoniae</i>. To date VED has prevented development of an efficacious vaccine against this significant human respiratory pathogen. Herein we report that vaccination of BALB/c mice with <i>M. pneumoniae</i> lipid-associated membrane proteins (LAMPs) induces lung lesions consistent with exacerbated disease following challenge, without reducing bacterial loads. Removal of lipid moiet  ...[more]

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