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Data in support of Mass spectrometric analysis of the in vitro secretome from equine bone marrow-derived mesenchymal stromal cells

ABSTRACT: Osteoarthritis (OA) including joint inflammation and cartilage degradation is one of the leading causes of lameness in horses, but there is still no cure to prevent the progressive degradation of the joint tissue or restore normal joint anatomy. Therefore, the goals for the treatments used for decades has been to slow the progression of the disease, minimize pain, and increase the function of the joint. The aim of this study was to investigate differences in the in vitro secreted protein profile between naïve and chondrogenic differentiating BM-derived MSCs when exposed to an inflammatory (IL-1) environment.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Equus Caballus (horse)

DISEASE(S): Wounds And Injuries

SUBMITTER: Allan Stensballe

LAB HEAD: Allan Stensballe

PROVIDER: PXD016842 | Pride | 2020-05-25

REPOSITORIES: Pride

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Mass spectrometric analysis of the in vitro secretome from equine bone marrow-derived mesenchymal stromal cells to assess the effect of chondrogenic differentiation on response to interleukin-1β treatment.

Bundgaard Louise L Stensballe Allan A Elbæk Kirstine Juul KJ Berg Lise Charlotte LC

Stem cell research & therapy 20200520 1

<h4>Background</h4>Similar to humans, the horse is a long-lived, athletic species. The use of mesenchymal stromal cells (MSCs) is a relatively new frontier, but has been used with promising results in treating joint diseases, e.g., osteoarthritis. It is believed that MSCs exert their main therapeutic effects through secreted trophic biomolecules. Therefore, it has been increasingly important to characterize the MSC secretome. It has been shown that the effect of the MSCs is strongly influenced b ...[more]

PMID: 32434555

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			Action	DRS
	10a_10d_BMEM_IL1.raw	Raw
	10b_10d_BMEM_IL1.raw	Raw
	10c_10d_BMEM_IL1.raw	Raw
	11a_10d_BMCM_IL1.raw	Raw
	11b_10d_BMCM_IL1.raw	Raw