Identification of HLA class I-presented peptides in MSI CRC model cell line HCT-116
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ABSTRACT: HCT-116 cells were treated either with 5 µM of the NMD inhibitor 5-azacytidine (PMID: 25319547) or DMSO (negative solvent control) for 24 h to examine differences in HLA class I-mediated peptide presentation. Moreover, data were used for the identification of tumor-specific neoepitopes originating from insertion/deletion mutations due to microsatellite instability.
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: Jonas Becker
LAB HEAD: Andreas E. Kulozik
PROVIDER: PXD021755 | Pride | 2021-04-14
REPOSITORIES: pride
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