Dataset Information

Data in support of Inflammatory Profile of Glucocorticoid Responsive Polymyalgia Rheumatica Patients

ABSTRACT: Polymyalgia rheumatica (PMR) is a systemic inflammatory disorder with unknown etiology and overlapping symptoms with giant cell arthritis and rheumatoid arthritis (RA). The inflammatory pathogenesis in PMR remain poorly uncharacterized and biomarker studies very limited. The primary aim of this study was to thoroughly investigate the serum proteome and pro-/anti-inflammatory response during at debut and post-glucocorticoid treatment in comparison to DMARD-naïve RA patients, and healthy controls. Treatment naïve patients PMR patients were included and samples were obtained prior to treatment and after 3 months of treatment. Disease-modifying anti-rheumatic drug (DMARD) naïve RA patients with matched healthy controls were included for comparisons.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Polymyalgia Rheumatica

SUBMITTER: Allan Stensballe

LAB HEAD: Allan Stensballe

PROVIDER: PXD016870 | Pride | 2024-06-16

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	MaxQuant_Combined_txt.zip	Other
	c10_1_GF3_01_1619.d.ZIP	Other
	c10_2_GF9_01_1625.d.ZIP	Other
	c10_3_RF7_01_1708.d.ZIP	Other
	c10_4_RG2_01_1720.d.ZIP	Other

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Publications

Naïve Inflammatory Proteome Profiles of Glucocorticoid Responsive Polymyalgia Rheumatica and Rheumatic Arthritis Patients-Links to Triggers and Proteomic Manifestations.

Stensballe Allan A Andersen Jacob Skallerup JS Aboo Christopher C Andersen Anders Borg AB Ren Jie J Meyer Michael Kruse MK Lambertsen Kate Lykke KL Leutscher Peter Derek Christian PDC

Journal of personalized medicine 20240425 5

Polymyalgia rheumatica (PMR) is an inflammatory disorder of unknown etiology, sharing symptoms with giant cell arthritis (GCA) and rheumatoid arthritis (RA). The pathogenic inflammatory roots are still not well understood, and there is a lack of extensive biomarker studies to explain the disease debut and post-acute phase. This study aimed to deeply analyze the serum proteome and inflammatory response of PMR patients before and after glucocorticoid treatment. We included treatment-naïve PMR pati ...[more]

PMID: 38793033

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