Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Astrocyte
SUBMITTER: Cory Willis
LAB HEAD: Stephen J Crocker
PROVIDER: PXD017058 | Pride | 2020-05-27
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 10 |
Willis Cory M CM Nicaise Alexandra M AM Bongarzone Ernesto R ER Givogri Maria M Reiter Cory R CR Heintz Olivia O Jellison Evan R ER Sutter Pearl A PA TeHennepe Gregg G Ananda Guruprasad G Vella Anthony T AT Crocker Stephen J SJ
Scientific reports 20200121 1
The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy and aging has been implicated as a basis for these pathological changes. Aging tissues accumulate chronic cellular stress, which can lead to the development of a pro-inflammatory phenotype that can be associated with cellular senescence. Herein, we provide evidence t ...[more]