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Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

ABSTRACT: Extracellular vesicles isolated from the conditioned media of short, long-term, and rapamycin treated long-term cultured astrocytes were subjected to proteomic analysis to determine the how the EV proteome changes following long-term culture.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Astrocyte

SUBMITTER: Cory Willis

LAB HEAD: Stephen J Crocker

PROVIDER: PXD017058 | Pride | 2020-05-27

REPOSITORIES: Pride

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			Action	DRS
	OTF18-1208_Crocker_Young_Astrocyte_Exosomes_1.raw	Raw
	OTF18-1212_Crocker_Aged_Astrocyte_Rapamycin_Exosomes_1.raw	Raw
	OTF18-1216_Crocker_Young_Astrocyte_Exosomes_2.raw	Raw
	OTF18-1228_Crocker_Aged_Astrocyte_Rapamycin_Exosomes_2.raw	Raw
	OTF18-1236_Crocker_Aged_Astrocyte_Rapamycin_Exosomes_3.raw	Raw

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Publications

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age.

Willis Cory M CM Nicaise Alexandra M AM Bongarzone Ernesto R ER Givogri Maria M Reiter Cory R CR Heintz Olivia O Jellison Evan R ER Sutter Pearl A PA TeHennepe Gregg G Ananda Guruprasad G Vella Anthony T AT Crocker Stephen J SJ

Scientific reports 20200121 1

The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy and aging has been implicated as a basis for these pathological changes. Aging tissues accumulate chronic cellular stress, which can lead to the development of a pro-inflammatory phenotype that can be associated with cellular senescence. Herein, we provide evidence t ...[more]

PMID: 31964978

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