Proteomics

Dataset Information

0

Tau posttranslational modifications


ABSTRACT: Human tauopathies including Alzheimer's disease are characterized by alterations in the post-translational modification (PTM) pattern of Tau, leading to the formation of insoluble aggregates, neuronal dysfunction and degeneration. We immunoprecipitated Tau from post-mortem brain tissue of early stage Alzheimer's disease patients and age-matched controls, and analyzed PTMs on this soluble pool of Tau protein. In addition to known serine, threonine and tyrosine phosphorylation events, we identified a number of previously unknown monomethylation events on lysines in both control and Alzheimer's patient tissues.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Dagmar Ehrnhoefer  

LAB HEAD: Dagmar E. Ehrnhoefer

PROVIDER: PXD017065 | Pride | 2021-09-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
171121_P0509_PH_BioMedX_band42_T_R1.raw Raw
171121_P0509_PH_BioMedX_band45_T_R1.raw Raw
F063052.dat Other
F063053.dat Other
Items per page:
1 - 4 of 4
altmetric image

Publications


<h4>Background</h4>Human tauopathies including Alzheimer's disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neuronal dysfunction and degeneration. While PTMs on aggregated Tau have been studied in detail, much less is known about the modification patterns of soluble Tau. Furthermore, PTMs other than phosphorylation have only come into focus recently and are still understudied. Solu  ...[more]

Similar Datasets

2021-09-16 | E-MTAB-5742 | biostudies-arrayexpress
2016-02-17 | E-GEOD-53697 | biostudies-arrayexpress
2016-02-17 | E-GEOD-53695 | biostudies-arrayexpress
2022-05-19 | PXD031417 | Pride
2022-08-01 | E-MTAB-11983 | biostudies-arrayexpress
2021-09-08 | PXD010807 | Pride
2014-04-21 | E-GEOD-48350 | biostudies-arrayexpress
2016-08-24 | PXD002516 | Pride
2016-04-16 | E-MTAB-4185 | biostudies-arrayexpress
2020-02-11 | E-MTAB-8712 | biostudies-arrayexpress