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Human Brain LC-MS/MS - Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

ABSTRACT: Brian Protein Deamidation Associated with Amyloidosis Revealed by Soluble and Amyloidal Brian Proteome Profiling

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Sunil Adav

LAB HEAD: Siu-Kwan Sze

PROVIDER: PXD002516 | Pride | 2016-08-24

REPOSITORIES: pride

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			Action	DRS
	131023_Sunil_PPT_Brain_A_01.raw	Raw
	131023_Sunil_PPT_Brain_A_02.raw	Raw
	131023_Sunil_PPT_Brain_A_03.raw	Raw
	131023_Sunil_PPT_Brain_A_04.raw	Raw
	131023_Sunil_PPT_Brain_A_05.raw	Raw

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Publications

Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues.

Adav Sunil S SS Gallart-Palau Xavier X Tan Kok Hian KH Lim Sai Kiang SK Tam James P JP Sze Siu Kwan SK

Molecular brain 20160219

<h4>Background</h4>Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia.<h4>Results</h4>To characterize amyloidal plaque purified from post-mortem brain tissue of dementia patient, we applied ultracentrifugation-electrostatic repulsion hydrophilic interaction chromatography (UC-ERLIC) coupled mas ...[more]

PMID: 26892330

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