Dataset Information

Quantitative proteomic analysis of SFTSV infected THP-1 cells

ABSTRACT: Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus causing a high fatality of 12-50% in infected patients. In-depth understanding of the SFTSV induced pathogenesis mechanism is critical for developing effective anti-SFTS therapeutics.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Leike Zhang

LAB HEAD: Leike Zhang

PROVIDER: PXD017224 | Pride | 2022-09-05

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20180215_ZLK_iTRAQ_1-1-15UniProt_HumanPhlebovirus-WCH97HNChina2011_ProteinSummary.txt	Txt
	20180215_ZLK_iTRAQ_1-1.wiff	Wiff
	20180215_ZLK_iTRAQ_1-1.wiff.scan	Wiff
	20180215_ZLK_iTRAQ_1-10.wiff	Wiff
	20180215_ZLK_iTRAQ_1-10.wiff.scan	Wiff

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Publications

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation.

Li Shufen S Li Hao H Zhang Yu-Lan YL Xin Qi-Lin QL Guan Zhen-Qiong ZQ Chen Xi X Zhang Xiao-Ai XA Li Xiao-Kun XK Xiao Geng-Fu GF Lozach Pierre-Yves PY Cui Jun J Liu Wei W Zhang Lei-Ke LK Peng Ke K

Cell reports 20200301 13

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus that carries a high fatality rate of 12%-50%. In-depth understanding of the SFTSV-induced pathogenesis mechanism is critical for developing effective anti-SFTS therapeutics. Here, we report transcriptomic analysis of blood samples from SFTS patients. We observe a strong correlation between inflammatory responses and disease progression and fatal outcome. Quantitative proteomic analysis of SFTSV infec ...[more]

PMID: 32234474

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