Proteomics

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HEK293T cell degradome (pulse chase) analysis upon 12h Torin1 treatment. Related to Supplementary Table 3 from An et al (2020)

ABSTRACT: HEK293T Azidohomoalanine (AHA) Pulse Chase (degradome) experiment, were cells from various genetic background (WT, ATG7-/-, RB1CC1-/-) are treated or not with Torin1 for 12h. Samples are Biotin-click, and streptavidin enriched.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: Alban Ordureau  

LAB HEAD: Wade Harper

PROVIDER: PXD017857 | Pride | 2020-04-30

REPOSITORIES: Pride

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407667_HA_9_52_3_F12_hUNI_Stdmod_TMT_10Plex_Comet_TrypNoP.mzIdentML Mzid
407668_HA_9_52_3_F11_hUNI_Stdmod_TMT_10Plex_Comet_TrypNoP.mzIdentML Mzid
407669_HA_9_52_3_F10_hUNI_Stdmod_TMT_10Plex_Comet_TrypNoP.mzIdentML Mzid
407670_HA_9_52_3_F09_hUNI_Stdmod_TMT_10Plex_Comet_TrypNoP.mzIdentML Mzid
407671_HA_9_52_3_F08_hUNI_Stdmod_TMT_10Plex_Comet_TrypNoP.mzIdentML Mzid
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Publications

Systematic quantitative analysis of ribosome inventory during nutrient stress.

An Heeseon H   Ordureau Alban A   Körner Maria M   Paulo Joao A JA   Harper J Wade JW  

Nature 20200701 7815

Mammalian cells reorganize their proteomes in response to nutrient stress through translational suppression and degradative mechanisms using the proteasome and autophagy systems<sup>1,2</sup>. Ribosomes are central targets of this response, as they are responsible for translation and subject to lysosomal turnover during nutrient stress<sup>3-5</sup>. The abundance of ribosomal (r)-proteins (around 6% of the proteome; 10<sup>7</sup> copies per cell)<sup>6,7</sup> and their high arginine and lysin  ...[more]

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