Proteomics

Dataset Information

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HEK293T cell nuclear & cytosolic phospho-proteome remodelling upon amino acid withdrawal. Related to Supplementary Table 4 from An et al (2020)

ABSTRACT: HEK293T Phospho proteome cytosolic vs nuclear fractionation upon short (3h) amino acids withdrawal.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: Alban Ordureau  

LAB HEAD: Wade Harper

PROVIDER: PXD017855 | Pride | 2020-04-30

REPOSITORIES: Pride

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412267_HA_7_48_Phos_F6_hUNI_pSTY_NQmod_TMT_11Plex_Comet.mzIdentML Mzid
412268_HA_7_48_Phos_F5_hUNI_pSTY_NQmod_TMT_11Plex_Comet.mzIdentML Mzid
412269_HA_7_48_Phos_F4_hUNI_pSTY_NQmod_TMT_11Plex_Comet.mzIdentML Mzid
412270_HA_7_48_Phos_F3_hUNI_pSTY_NQmod_TMT_11Plex_Comet.mzIdentML Mzid
412271_HA_7_48_Phos_F2_hUNI_pSTY_NQmod_TMT_11Plex_Comet.mzIdentML Mzid
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Publications

Systematic quantitative analysis of ribosome inventory during nutrient stress.

An Heeseon H   Ordureau Alban A   Körner Maria M   Paulo Joao A JA   Harper J Wade JW  

Nature 20200701 7815

Mammalian cells reorganize their proteomes in response to nutrient stress through translational suppression and degradative mechanisms using the proteasome and autophagy systems<sup>1,2</sup>. Ribosomes are central targets of this response, as they are responsible for translation and subject to lysosomal turnover during nutrient stress<sup>3-5</sup>. The abundance of ribosomal (r)-proteins (around 6% of the proteome; 10<sup>7</sup> copies per cell)<sup>6,7</sup> and their high arginine and lysin  ...[more]

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