Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neuroblast
DISEASE(S): Neuroblastoma
SUBMITTER: Evelin Berger
LAB HEAD: Carina Sihlbom
PROVIDER: PXD017946 | Pride | 2020-11-25
REPOSITORIES: Pride
Action | DRS | |||
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3062_Siaw_QMS_Fusion_190123_06-25-1.msf | Msf | |||
Fusion_190123_06.raw | Raw | |||
Fusion_190123_07.raw | Raw | |||
Fusion_190123_08.raw | Raw | |||
Fusion_190123_09.raw | Raw |
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Cell reports 20200901 12
High-risk neuroblastomas typically display an undifferentiated or poorly differentiated morphology. It is therefore vital to understand molecular mechanisms that block the differentiation process. We identify an important role for oncogenic ALK-ERK1/2-SP1 signaling in the maintenance of undifferentiated neural crest-derived progenitors through the repression of DLG2, a candidate tumor suppressor gene in neuroblastoma. DLG2 is expressed in the murine "bridge signature" that represents the transcr ...[more]