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Transcriptome and proteome profiling of motor neuron model subjected to protein misfolding stress

ABSTRACT: To identify molecular differences between closely related motor neurons relevant for understanding of neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), we exploited induced cranial and spinal motor neuron populations from mouse embryonic stem cells. We performed a large scale time-dependent TMT-based proteomics analysis in the presence and absence of protein misfolding stress. We profiled ~8,600 proteins from two different motor neuron cell lines, measured in two replicates and three time points.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryonic Stem Cell

SUBMITTER: Shuvadeep Maity

LAB HEAD: Christine Vogel

PROVIDER: PXD018070 | Pride | 2024-03-06

REPOSITORIES: Pride

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			Action	DRS
	171226_TMT_NIP_NIL_set2.msf	Msf
	171226_TMT_NIP_NIL_set2.msfView	Msf
	171226_TMT_NIP_NIL_set2.pdResult	Other
	171226_TMT_NIP_NIL_set2.pdResultView	Other
	171226_TMT_NIP_NIL_set2_MSMSSpectrumInfo.txt	Txt

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