Dataset Information

Characterization of HEK293 secretome by LC-MS/MS

ABSTRACT: Characterization of the extracellular environment of produced VLPs and coproduced extracellular vesicles (EVs)by quantitative proteomics approach. Three conditions were studied: non-transfected, transfected with an empty plasmid as control and with a plasmid coding for HIV-1 Gag polyprotein.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Inmaculada Jorge

LAB HEAD: Jesús Vázquez Cobos

PROVIDER: PXD018114 | Pride | 2020-09-28

REPOSITORIES: Pride

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Publications

Molecular Characterization of the Coproduced Extracellular Vesicles in HEK293 during Virus-Like Particle Production.

Lavado-García Jesús J González-Domínguez Irene I Cervera Laura L Jorge Inmaculada I Vázquez Jesús J Gòdia Francesc F

Journal of proteome research 20201005 11

Vaccine therapies based on virus-like particles (VLPs) are currently in the spotlight due to their potential for generating high immunogenic responses while presenting fewer side effects than conventional vaccines. These self-assembled nanostructures resemble the native conformation of the virus but lack genetic material. They are becoming a promising platform for vaccine candidates against several diseases due to the ability of modifying their membrane with antigens from different viruses. The ...[more]

PMID: 32975947

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			Action	DRS
	FR_Ultra_1.msf	Msf
	FR_Ultra_1.raw	Raw
	FR_Ultra_1_180506224145.msf	Msf
	FR_Ultra_1_180506224145.raw	Raw
	FR_Ultra_2.msf	Msf