Dataset Information

Multiplexed quantitative proteomic analysis of Human Embryonic Kidney 293 (HEK293)

ABSTRACT: Study of the changes in the HEK293 proteome when growing without transfection, when transfected with an empty plasmid and when transfected with Gagcoding gene to produce Gag VLPs,

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Early Embryonic Cell

SUBMITTER: Inmaculada Jorge

LAB HEAD: Jesús Vázquez Cobos

PROVIDER: PXD014746 | Pride | 2020-05-15

REPOSITORIES: Pride

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Publications

Multiplexed Quantitative Proteomic Analysis of HEK293 Provides Insights into Molecular Changes Associated with the Cell Density Effect, Transient Transfection, and Virus-Like Particle Production.

Lavado-García Jesús J Jorge Inmaculada I Cervera Laura L Vázquez Jesús J Gòdia Francesc F

Journal of proteome research 20200207 3

The production of virus-like particles (VLPs) has gained importance over the last few years owing to the benefits they provide compared to conventional vaccines. The biopharmaceutical industry is currently searching for safer candidates based on VLPs for new and existing vaccines and implementing new methods of manufacturing, thus allowing a more sustainable, effective, and species-specific production. Despite achieving lower yields compared to traditional platforms, the use of mammalian cells p ...[more]

PMID: 31994890

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	FR_P2_1.msf	Msf
	FR_P2_1.raw	Raw
	FR_P2_1_180505060744.msf	Msf
	FR_P2_1_180505060744.raw	Raw
	FR_P2_2.msf	Msf