Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: Francesca Fabretti
LAB HEAD: Bernhard Schermer
PROVIDER: PXD018143 | Pride | 2020-05-06
REPOSITORIES: Pride
Items per page: 1 - 5 of 11 |
Nucleic acids research 20200601 11
Originally identified as an RNA polymerase II interactor, Che-1/AATF (Che-1) has now been recognized as a multifunctional protein involved in cell-cycle regulation and cancer progression, as well as apoptosis inhibition and response to stress. This protein displays a peculiar nucleolar localization and it has recently been implicated in pre-rRNA processing and ribosome biogenesis. Here, we report the identification of a novel function of Che-1 in the regulation of ribosomal RNA (rRNA) synthesis, ...[more]