Proteomics

Dataset Information

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Cell wall and secretome of Candida albicans WT, hir1delta/delta strain, and HIR1 complemented mutant


ABSTRACT: Cell wall and secretome of Candida albicans WT, hir1delta/delta strain, and HIR1 complemented mutant using SWATH MS.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Candida Albicans (yeast)

SUBMITTER: Lucia Zacchi  

LAB HEAD: Lucia Florencia Zacchi

PROVIDER: PXD018163 | Pride | 2022-02-15

REPOSITORIES: Pride

Dataset's files

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Publications


Adaptation to changing environments and immune evasion is pivotal for fitness of pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation is governed by dynamic transcriptional re-programming, which is tightly connected to chromatin architecture. Here, we report a pivotal role for the HIR histone chaperone complex in modulating virulence of the human fungal pathogen Candida albicans. Genetic ablation of HIR function alters chromatin accessibility linked to aberrant transcript  ...[more]

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