Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture
SUBMITTER: Gregory Lizee
LAB HEAD: Greg Lizee
PROVIDER: PXD018302 | Pride | 2020-10-19
REPOSITORIES: Pride
Action | DRS | |||
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032917mhc-res-AHT506-MS05-1-MP81.raw | Raw | |||
032917mhc-res-AHT506-MS05-1-MP81_psms.txt | Txt | |||
050215mhc-hMIA-2d.raw | Raw | |||
050215mhc-hMIA-2d_psms.txt | Txt |
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Bradley Sherille D SD Talukder Amjad H AH Lai Ivy I Davis Rebecca R Alvarez Hector H Tiriac Herve H Zhang Minying M Chiu Yulun Y Melendez Brenda B Jackson Kyle R KR Katailiha Arjun A Sonnemann Heather M HM Li Fenge F Kang Yaan Y Qiao Na N Pan Bih-Fang BF Lorenzi Philip L PL Hurd Mark M Mittendorf Elizabeth A EA Peterson Christine B CB Javle Milind M Bristow Christopher C Kim Michael M Tuveson David A DA Hawke David D Kopetz Scott S Wolff Robert A RA Hwu Patrick P Maitra Anirban A Roszik Jason J Yee Cassian C Lizée Gregory G
Nature communications 20201021 1
Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for inducing clinical regressions by targeting tumor-associated antigens (TAA). To expand the TAA landscape of pancreatic ductal adenocarcinoma (PDAC), we performed tandem mass spectrometry analysis of HLA class I-bound peptides from 35 PDAC patient tumors. This identified a shared HLA-A*0101 restricted peptide derived from co-transcriptional activator Vestigial-like 1 (VGLL1) as a putative TAA demonstrating overe ...[more]