Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Donald Wolfgeher
LAB HEAD: Dr. Stephen Kron
PROVIDER: PXD018549 | Pride | 2021-03-24
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
181010_TOPO_123_Human_Iso.fasta | Fasta | |||
190205_DW29_Index.txt | Txt | |||
190318_Top1_New_HNE_MQ.xml | Xml | |||
190822_DW35_Inc_List.csv | Csv | |||
190823_DW29_Index.txt | Txt |
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Cell chemical biology 20201221 6
Topoisomerase 1 (Top1) reversibly nicks chromosomal DNA to relax strain accumulated during transcription, replication, chromatin assembly, and chromosome condensation. The Top1 poison camptothecin targets cancer cells by trapping the enzyme in the covalent complex Top1<sub>cc</sub>, tethered to cleaved DNA by a tyrosine-3'-phosphate bond. In vitro mechanistic studies point to interfacial inhibition, where camptothecin binding to the Top1-DNA interface stabilizes Top1<sub>cc</sub>. Here we presen ...[more]