Dataset Information

Drosophila nephrocytes Bazooka knockdown vs control

ABSTRACT: We assessed the functional role of the cell polarity protein Bazooka on nephrocyte function. Here, we did a proteomics anaylsis of isolated garland nephrocytes from 3rd install larvae. Analysis of the data identified several differentially regulated proteins.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Nephrocyte

SUBMITTER: Martin Hoehne

LAB HEAD: Paul Thomas Brinkkoetter

PROVIDER: PXD018635 | Pride | 2022-07-07

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20190310_Q4_UC_ColID_814_ProjID_1640_Benzing_01.raw	Raw
	20190310_Q4_UC_ColID_814_ProjID_1640_Benzing_02.raw	Raw
	20190310_Q4_UC_ColID_814_ProjID_1640_Benzing_03.raw	Raw
	20190310_Q4_UC_ColID_814_ProjID_1640_Benzing_04.raw	Raw
	20190310_Q4_UC_ColID_814_ProjID_1640_Benzing_05.raw	Raw

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Publications

Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier.

Koehler Sybille S Odenthal Johanna J Ludwig Vivian V Unnersjö Jess David D Höhne Martin M Jüngst Christian C Grawe Ferdi F Helmstädter Martin M Janku Johanna L JL Bergmann Carsten C Hoyer Peter F PF Hagmann H Henning HH Walz Gerd G Bloch Wilhelm W Niessen Carien C Schermer Bernhard B Wodarz Andreas A Denholm Barry B Benzing Thomas T Iden Sandra S Brinkkoetter Paul T PT

Kidney international 20211217 4

Glomerular diseases are a major cause for chronic kidney disorders. In most cases podocyte injury is causative for disease development. Cytoskeletal rearrangements and morphological changes are hallmark features of podocyte injury and result in dedifferentiation and loss of podocytes. Here, we establish a link between the Par3 polarity complex and actin regulators necessary to establish and maintain podocyte architecture by utilizing mouse and Drosophila models to characterize the functional rol ...[more]

PMID: 34929254

Dataset Information

Drosophila nephrocytes Bazooka knockdown vs control

Dataset's files

Publications

Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier.

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