Proteomics

Dataset Information

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TMT-based proteomics analysis of arachidonic acid (ARA) treated and control oocytes


ABSTRACT: Arachidonic acid (ARA) treated and control oocytes in 3 replicates were subjected to the 6-plex TMT labeling, HP-RP fractionation, and LC-MS/MS analysis.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Oocyte

DISEASE(S): Disease Free

SUBMITTER: Xuejiang Guo  

LAB HEAD: Xuejiang Guo

PROVIDER: PXD018753 | Pride | 2022-02-15

REPOSITORIES: Pride

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Publications


Well-balanced and timed metabolism is essential for making a high-quality egg. However, the metabolic framework that supports oocyte development remains poorly understood. Here, we obtained the temporal metabolome profiles of mouse oocytes during in vivo maturation by isolating large number of cells at key stages. In parallel, quantitative proteomic analyses were conducted to bolster the metabolomic data, synergistically depicting the global metabolic patterns in oocytes. In particular, we disco  ...[more]

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