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RNA sequencing to determine gene expression changes in Siglec-15 knockdown oteosarcoma cells

ABSTRACT: In our study, we found that Siglec-15 was critical to osteosarcoma characteristics. To identify the downstream target genes of Siglec-15 in osteosarcoma, we conducted the RNA-seq analysis of Siglec-15 knockdown in osteosarcoma cell line 143B cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE175414 | GEO | 2021/05/25

REPOSITORIES: GEO

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Effect of deficiency of Siglec-15 during osteoclast differentiation of murine bone marrow macrophages

Project description:To investigate the function of Siglec-15 in the regulation of osteoclast differentiation, Siglec-15 deficient mice was established. Then gene expression profiling analysis using data obtained from RNA-seq of bone marrow macrophages with M-CSF and RANKL at two different time points was performed.

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RNA sequencing to determine gene expression changes in Siglec-15 knockdown oteosarcoma cells

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Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

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Tumor-derived kynurenine induces Siglec-15 expression and promotes CD8+T cell exhaustion in oral squamous cell carcinoma

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Identification of ALKBH5 targets in osteosarcoma by methyl RNA immunoprecipitation [MeRIP-seq]

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Gene regulation by m6A demethylase ALKBH5 in osteosarcoma [RNA-seq]

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Expression profiling of 143B-shCtrl and 143B-shIRX1 stable osteosarcoma cell lines

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Type-I interferon inducible genes 26 weeks after mCMV infection in Siglec-H wt and Siglec-H ko mice and their non infected controls

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