Proteomics

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Staphylococcus aureus membrane vesicles confer resistance to antimicrobial fatty acids

ABSTRACT: S. aureus is a common commensal inhabitant of skin and nares of healthy individuals. In these environments, S. aureus overcomes colonisation barriers deployed by the innate immune system, which include long chain unsaturated free fatty acids with known potent anti-staphylococcal activity. S. aureus resistance mechanisms to these antimicrobial fatty acids (AFAs) remain elusive. However, it is well-documented that AFAs target S. aureus membrane, and increase its fluidity. This is associated with a drastic change in secreted proteins. The most abundantly secreted proteins in response to AFAs were recently identified to be components of S. aureus membrane vesicles (MVs), as revealed by proteomics analyses. Here, we demonstrate that MVs are decoys that trap AFAs. Importantly, MV release and composition are modulated by AFAs to promote bacterial survival.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Nicolas Nalpas  

LAB HEAD: Prof. Dr. Andreas Peschel

PROVIDER: PXD018809 | Pride | 2021-09-09

REPOSITORIES: Pride

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Publications

Staphylococcus aureus Releases Proinflammatory Membrane Vesicles To Resist Antimicrobial Fatty Acids.

Kengmo Tchoupa Arnaud A   Peschel Andreas A  

mSphere 20200930 5

<i>Staphylococcus aureus</i> is a major pathogen, which colonizes one in three otherwise healthy humans. This significant spread of <i>S. aureus</i> is largely due to its ability to circumvent innate immune responses, including antimicrobial fatty acids (AFAs) on the skin and in nasal secretions. In response to AFAs, <i>S. aureus</i> swiftly induces resistance mechanisms, which have yet to be completely elucidated. Here, we identify membrane vesicle (MV) release as a resistance strategy used by  ...[more]

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