Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Toxoplasma Gondii Gt1
SUBMITTER: Alice Herneisen
LAB HEAD: Sebastian Lourido
PROVIDER: PXD018810 | Pride | 2020-07-13
REPOSITORIES: Pride
Items per page: 1 - 5 of 24 |
ACS chemical biology 20200706 7
Apicomplexan parasites include the causative agents of malaria and toxoplasmosis. Cell-based screens in <i>Toxoplasma</i> previously identified a chemical modulator of calcium signaling (ENH1) that blocked parasite egress from host cells and exhibited potent antiparasitic activity. To identify the targets of ENH1, we adapted thermal proteome profiling to <i>Toxoplasma</i>, which revealed calcium-dependent protein kinase 1 (CDPK1) as a target. We confirmed the inhibition of CDPK1 by ENH1 in vitro ...[more]