Dataset Information
Phospho-proteomic data on the LATS1 interactome from cells treated with two proapoptotic signals: FAS and etoposide
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cervical Cell Line
DISEASE(S): Cervical Cancer
SUBMITTER: 
David Matallanas
LAB HEAD: David Gomez
PROVIDER: PXD018903 | Pride | 2021-09-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 04072014_BT_Emma_ETO4.raw | Raw | |||
| 04072014_BT_Emma_ETO4_140707140621.raw | Raw | |||
| 04072014_BT_Emma_ETO5.raw | Raw | |||
| 04072014_BT_Emma_ETO5_140710141817.raw | Raw | |||
| 04072014_BT_Emma_ETO6.raw | Raw |
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Publications
IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway.
Cells 20210223 2
The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of the pathway with other signalling pathways and play an important role in the diverse output controlled by this pathway. In this study we have identified the scaffold protein IQGAP1 as a novel interactor of the core kinases of the Hippo pathway, MST2 and LATS1. Our results ind ...[more]
