Proteomics

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BioID screen for Uhrf2 interactors in AML12 cells

ABSTRACT: We identified the ubiquitin ligase Uhrf2 as an important regulator of liver regeneration. To gain insight into the mechanisms of action of Uhrf2 in hepatocytes, we searched for Uhrf2 interactors in the AML12 hepatocyte cell line using BioID interaction screening. This resulted in the identification of major chromatin remodelling proteins as Uhrf2 interactors.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hepatocyte

SUBMITTER: Coenraad Frederik Slabber  

LAB HEAD: Prof. Dr. Sabine Werner

PROVIDER: PXD041732 | Pride | 2023-06-01

REPOSITORIES: Pride

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20190405_004_S195025_Myc_DOX_3_Group_6.mzid_20190405_004_S195025_Myc_DOX_3_Group_6.MGF Mzid
20190405_004_S195025_Myc_DOX_3_Group_6.raw Raw
20190405_005_S195019_Myc_DOX_MG132_1_Group_8.mzid_20190405_005_S195019_Myc_DOX_MG132_1_Group_8.MGF Mzid
20190405_005_S195019_Myc_DOX_MG132_1_Group_8.raw Raw
20190405_006_S195015_HA_DOX_MG132_3_Group_4.mzid_20190405_006_S195015_HA_DOX_MG132_3_Group_4.MGF Mzid
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Publications

Fibroblast growth factors (FGFs) are key regulators of the remarkable regenerative capacity of the liver. Mice lacking FGF receptors 1 and 2 (Fgfr1 and Fgfr2) in hepatocytes are hypersensitive to cytotoxic injury during liver regeneration. Using these mice as a model for impaired liver regeneration, we identified a critical role for the ubiquitin ligase Uhrf2 in protecting hepatocytes from bile acid accumulation during liver regeneration. During regeneration after partial hepatectomy, <i>Uhrf2</  ...[more]

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