Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Bronchial Epithelial Cell, Epithelial Cell
DISEASE(S): Cystic Fibrosis
SUBMITTER: Alexander Capraro
LAB HEAD: Shafagh Waters
PROVIDER: PXD019084 | Pride | 2021-09-09
REPOSITORIES: Pride
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Antioxidants (Basel, Switzerland) 20201130 12
Systemic glutathione deficiency, inflammation, and oxidative stress are hallmarks of cystic fibrosis (CF), an inherited disease that causes persistent lung infections and severe damage to the respiratory system and many of the body organs. Improvements to current antioxidant therapeutic strategies are needed. The dietary supplement, γ-glutamylcysteine (GGC), which is the immediate precursor to glutathione, rapidly boosts cellular glutathione levels following a single dose in healthy individuals. ...[more]