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Proteome profilling of chromophobe renal cell carcinomas

ABSTRACT: LC-MS/MS based proteomics study of chromophobe renal cell carcinomas versus the adjacent healthy kidney tissues, nine patients included. The chromophobe renal cell carcinoma cells (UOK276) under different conditions were also analyzed.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Chromophobe Renal Cell Carcinoma Cell, Kidney

DISEASE(S): Chromophobe Renal Cell Carcinoma

SUBMITTER: Yi Xiao

LAB HEAD: David Meierhofer

PROVIDER: PXD019123 | Pride | 2020-07-23

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	UOK276_100AA_no_BSA_1_1D.index	Other
	UOK276_100AA_no_BSA_1_1D.raw	Raw
	UOK276_100AA_no_BSA_1_SCX_3.index	Other
	UOK276_100AA_no_BSA_1_SCX_3.raw	Raw
	UOK276_100AA_no_BSA_1_SCX_4.index	Other

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Publications

Decreased Mitochondrial DNA Content Drives OXPHOS Dysregulation in Chromophobe Renal Cell Carcinoma.

Xiao Yi Y Clima Rosanna R Busch Jonas J Rabien Anja A Kilic Ergin E Villegas Sonia L SL Timmermann Bernd B Attimonelli Marcella M Jung Klaus K Meierhofer David D

Cancer research 20200721 18

Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are closely related, rare kidney tumors. Mutations in complex I (CI)-encoding genes play an important role in dysfunction of the oxidative phosphorylation (OXPHOS) system in renal oncocytoma, but are less frequently observed in chRCC. As such, the relevance of OXPHOS status and role of CI mutations in chRCC remain unknown. To address this issue, we performed proteome and metabolome profiling as well as mitochondrial whole-exome sequen ...[more]

PMID: 32694149

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proteome profilling of chromophobe renal cell carcinomas

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Chromophobe renal cell carcinoma versus renal oncocytoma: a proteomic approach

Project description:The proteome of clinical tissue samples diagnosed with chromophobe renal cell carcinomas (chRCC) and renal oncocytomas (RO) were evaluated to establish a potential discriminative biomarker panel of proteins for these two tumors subtypes.

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microRNA profiling in renal carcinoma

Project description:Renal cell carcinoma comprises a variety of entities, the most common being the clear-cell, papillary and chromophobe subtypes. These subtypes are related to different clinical evolution; however, most therapies have been developed for clear-cell carcinoma and there is not a specific treatment based on different subtypes. In this study, one hundred and sixty-four paraffin samples from primary nephrectomies for localized tumors were analyzed. MiRNAs were isolated and measured by microRNA arrays. Significance Analysis of Microarrays and Consensus Cluster algorithm were used to characterize different renal subtypes. The analyses showed that chromophobe renal tumors are a homogeneous group characterized by an overexpression of miR 1229, miR 10a, miR 182, miR 1208, miR 222, miR 221, miR 891b, miR 629-5p and miR 221-5p. On the other hand, clear cell renal carcinomas presented two different groups inside this histological subtype, with differences in miRNAs that regulate focal adhesion, transcription, apoptosis and angiogenesis processes. Specifically, one of the defined groups had an overexpression of proangiogenic microRNAs miR185, miR126 and miR130a. In conclusion, differences in miRNA expression profiles between histological renal subtypes were established. In addition, clear cell renal carcinomas had different expression of proangiogenic miRNAs. With the emergence of antiangiogenic drugs, these differences could be used as therapeutic targets in the future or as a selection method for tailoring personalized treatments.

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