Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): T Cell, Lymph Node
SUBMITTER: Julia Marchingo
LAB HEAD: Doreen Ann Cantrell
PROVIDER: PXD016105 | Pride | 2020-02-25
REPOSITORIES: Pride
eLife 20200205
T cell expansion and differentiation are critically dependent on the transcription factor c-Myc (Myc). Herein we use quantitative mass-spectrometry to reveal how Myc controls antigen receptor driven cell growth and proteome restructuring in murine T cells. Analysis of copy numbers per cell of >7000 proteins provides new understanding of the selective role of Myc in controlling the protein machinery that govern T cell fate. The data identify both Myc dependent and independent metabolic processes ...[more]