Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Glioblastoma
SUBMITTER: Joseph Evaristo
LAB HEAD: Fábio César Sousa Nogueira
PROVIDER: PXD019496 | Pride | 2021-09-09
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Katia_Analise_LCMS_2019_PD_Result.pdResult | Other | |||
QE-003463_Katia_ELU_A1-A.raw | Raw | |||
QE-003464_Katia_ELU_A1-B.raw | Raw | |||
QE-003465_Katia_ELU_A1-C.raw | Raw | |||
QE-003467_Katia_ELU_A2-A.raw | Raw |
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Clinical proteomics 20210426 1
Glioblastoma (GBM) is a grade IV glioma highly aggressive and refractory to the therapeutic approaches currently in use. O-GlcNAcylation plays a key role for tumor aggressiveness and progression in different types of cancer; however, experimental evidence of its involvement in GBM are still lacking. Here, we show that O-GlcNAcylation plays a critical role in maintaining the composition of the GBM secretome, whereas inhibition of OGA activity disrupts the intercellular signaling via microvesicles ...[more]