Dataset Information

Global proteome analysis of paired colorectal cancer sample using LC-MS/MS

ABSTRACT: To find differentially expressed protein in colorectal cancer compared with normal colon tissue, we performed global proteome analysis using LC-MS.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Atsushi Tanaka

LAB HEAD: Michael Roehrl

PROVIDER: PXD019504 | Pride | 2020-09-30

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	1417AT_S1_10R1_CRC5T_i39_MichaelRoehrl.raw	Raw
	1417AT_S1_11R1_CRC5N_i39_MichaelRoehrl.raw	Raw
	1417AT_S1_12R1_CRC6T_i39_MichaelRoehrl.raw	Raw
	1417AT_S1_13R1_CRC6N_i39_MichaelRoehrl.raw	Raw
	1417AT_S1_14R1_CRC7T_i39_MichaelRoehrl.raw	Raw

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Publications

Prolyl 4-hydroxylase alpha 1 protein expression risk-stratifies early stage colorectal cancer.

Tanaka Atsushi A Zhou Yihua Y Shia Jinru J Ginty Fiona F Ogawa Makiko M Klimstra David S DS Hendrickson Ronald C RC Wang Julia Y JY Roehrl Michael H MH

Oncotarget 20200225 8

Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies. Especially for early stage CRC, prognostic molecular markers are needed to guide therapy. In this study, we first extracted total proteomes from matched pairs of fresh cancer and benign mucosal tissues from 22 CRC patients. Global proteomic profiling with Fourier transform liquid chromatography-mass spectrometry sequencing and label free quantitation uncovered that P4HA1 (prolyl 4-hydroxylase alpha 1) was overexpressed ...[more]

PMID: 32166002

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