Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung
DISEASE(S): Lung Cancer
SUBMITTER: Georgios Mermelekas
LAB HEAD: Janne Lehtiö
PROVIDER: PXD020191 | Pride | 2021-12-15
REPOSITORIES: Pride
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Lehtiö Janne J Arslan Taner T Siavelis Ioannis I Pan Yanbo Y Socciarelli Fabio F Berkovska Olena O Umer Husen M HM Mermelekas Georgios G Pirmoradian Mohammad M Jönsson Mats M Brunnström Hans H Brustugun Odd Terje OT Purohit Krishna Pinganksha KP Cunningham Richard R Foroughi Asl Hassan H Isaksson Sofi S Arbajian Elsa E Aine Mattias M Karlsson Anna A Kotevska Marija M Gram Hansen Carsten C Drageset Haakensen Vilde V Helland Åslaug Å Tamborero David D Johansson Henrik J HJ Branca Rui M RM Planck Maria M Staaf Johan J Orre Lukas M LM
Nature cancer 20211122 11
Despite major advancements in lung cancer treatment, long-term survival is still rare, and a deeper understanding of molecular phenotypes would allow the identification of specific cancer dependencies and immune evasion mechanisms. Here we performed in-depth mass spectrometry (MS)-based proteogenomic analysis of 141 tumors representing all major histologies of non-small cell lung cancer (NSCLC). We identified six distinct proteome subtypes with striking differences in immune cell composition and ...[more]