Dataset Information

Proteomic Signatures of Acute Oxidative Stress Response to Paraquat in the Mouse Heart

ABSTRACT: Using quantitative tandem mass spectrometry, we assessed the effects of acute exposure of the oxidative stress inducer paraquat on protein expression in mouse hearts.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Lung

SUBMITTER: Maggie Pui Yu Lam

LAB HEAD: Maggie PY Lam

PROVIDER: PXD020199 | Pride | 2021-09-09

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20180321_PQ_HT_TMT_Block1_F1.pep.xml	Pepxml
	20180321_PQ_HT_TMT_Block1_F1.raw	Raw
	20180321_PQ_HT_TMT_Block1_F2.pep.xml	Pepxml
	20180321_PQ_HT_TMT_Block1_F2.raw	Raw
	20180321_PQ_HT_TMT_Block1_F3.pep.xml	Pepxml

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Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart.

Dostal Vishantie V Wood Silas D SD Thomas Cody T CT Han Yu Y Lau Edward E Lam Maggie P Y MPY

Scientific reports 20201028 1

The heart is sensitive to oxidative damage but a global view on how the cardiac proteome responds to oxidative stressors has yet to fully emerge. Using quantitative tandem mass spectrometry, we assessed the effects of acute exposure of the oxidative stress inducer paraquat on protein expression in mouse hearts. We observed widespread protein expression changes in the paraquat-exposed heart especially in organelle-containing subcellular fractions. During cardiac response to acute oxidative stress ...[more]

PMID: 33116222

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