Dataset Information

Comparison of Rheumatoid Arthritis Patient and Control Sample Serum Proteomes

ABSTRACT: Rheumatoid arthritis is an autoimmune inflammatory joint condition which primarily affects the synovium of joints, characterised by synovial inflammation as well as articular cartilage and underlying bone destruction. Within this study, the proteomes of serum obtained from rheumatoid arthritis patients, and appropriate human controls, were analysed using liquid chromatography-tandem mass spectrometry. ProteoMiner™ equalisation columns were used to deplete high abundant proteins and reduce the protein concentration dynamic range.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: James Anderson

LAB HEAD: Mandy Jayne Peffers

PROVIDER: PXD020235 | Pride | 2022-04-04

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	10_RA_RF_Positive_AntiCCP_Negative.mgf	Mgf
	10_RA_RF_Positive_AntiCCP_Negative.mzid.gz	Mzid
	10_RA_RF_Positive_AntiCCP_Negative.raw	Raw
	11_RA_RF_Negative_AntiCCP_Positive.mgf	Mgf
	11_RA_RF_Negative_AntiCCP_Positive.mzid.gz	Mzid

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Publications

LC-MS/MS-Based Serum Protein Profiling for Identification of Candidate Biomarkers in Pakistani Rheumatoid Arthritis Patients.

Jahangir Sidrah S John Peter P Bhatti Attya A Aslam Muhammad Muaaz MM Mehmood Malik Javaid J Anderson James R JR Peffers Mandy J MJ

Life (Basel, Switzerland) 20220321 3

Rheumatoid arthritis is an autoimmune disorder of complex disease etiology. Currently available serological diagnostic markers lack in terms of sensitivity and specificity and thus additional biomarkers are warranted for early disease diagnosis and management. We aimed to screen and compare serum proteome profiles of rheumatoid arthritis serotypes with healthy controls in the Pakistani population for identification of potential disease biomarkers. Serum samples from rheumatoid arthritis patients ...[more]

PMID: 35330214

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