Dataset Information

Small extracellular vesicles from skeletal muscle cells (human)

ABSTRACT: Quantitative comparison of the protein load of small extracellular vesicles released from human skeletal muscle cells prior and after electric pulse stimulation.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Stefan Lehr

LAB HEAD: Stefan Lehr

PROVIDER: PXD020278 | Pride | 2022-02-15

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	08062018_6552_M41_DIA_34w.raw	Raw
	08062018_6553_M41_EPS_DIA_34w.raw	Raw
	08062018_6557_M16_EPS_DIA_34w.raw	Raw
	13062018_6554_M41_DIA_34w.raw	Raw
	13062018_6555_M41_EPS_DIA_34w.raw	Raw

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Publications

Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males.

Apostolopoulou Maria M Mastrototaro Lucia L Hartwig Sonja S Pesta Dominik D Straßburger Klaus K de Filippo Elisabetta E Jelenik Tomas T Karusheva Yanislava Y Gancheva Sofiya S Markgraf Daniel D Herder Christian C Nair K Sreekumaran KS Reichert Andreas S AS Lehr Stefan S Müssig Karsten K Al-Hasani Hadi H Szendroedi Julia J Roden Michael M

Science advances 20211008 41

High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO<sub>2</sub>max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in males with or without type 2 diabetes [T2D and NDM (nondiabetic humans)]. However, despite identically higher VO<sub>2</sub>max, mainly insulin-resistant (IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along with lower inhibitory ...[more]

PMID: 34623918

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