Proteomics

Dataset Information

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Serum proteomics of infants in utero exposed to Zika virus without Congenital Zika Syndrome


ABSTRACT: In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in babies who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIKV in the uterus have complications included in abnormalities related to Congenital Zika Syndrome (CZS). The risk of complications after birth is not well documented, however, clinical evidence shows that 6% of babies exposed to ZIKV during pregnancy have complications present at birth, and this rate rises to 14% when medical monitoring is performed in all exposed babies, regardless of birth condition. Thus, the evaluation and monitoring of all exposed babies are of foremost importance as the development of late complications has been increasingly supported by clinical evidence. The identification of molecular markers in infants exposed to ZIKV without CZS could provide valuable means to improve their clinical monitoring. Here, we used a shotgun-proteomic approach to investigate molecular markers in the serum of infants without CZS symptoms but exposed to ZIKV intrauterine (ZIKV) compared to non-exposed controls (CTRL).

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Livia Rosa-Fernandes  

LAB HEAD: Giuseppe Palmisano

PROVIDER: PXD020294 | Pride | 2021-09-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
C01.raw Raw
C09.raw Raw
C128.raw Raw
C147.raw Raw
C166.raw Raw
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Publications

Serum Proteomics Reveals Alterations in Protease Activity, Axon Guidance, and Visual Phototransduction Pathways in Infants With <i>In Utero</i> Exposure to Zika Virus Without Congenital Zika Syndrome.

Macedo-da-Silva Janaina J   Rosa-Fernandes Lívia L   Barbosa Raquel Hora RH   Angeli Claudia B CB   Carvalho Fabiana Rabe FR   de Oliveira Vianna Renata Artimos RA   Carvalho Paulo C PC   Larsen Martin R MR   Cardoso Claudete Araújo CA   Palmisano Giuseppe G  

Frontiers in cellular and infection microbiology 20201118


In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in infants who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIKV in the uterus have complications included in abnormalities related to Congenital Zika Syndrome (CZS). The risk of complications after birth is not well documented, however, clinical evidence shows  ...[more]

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