Neuronal cells from ASL patients
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ABSTRACT: This study describes altered CREB-dependent activity related transcription, and disrupted synaptic composition as common pathological features in ALS. These aberrations are restored by Apamin and XE991, two K+ channel blockers targeting the SK and Kv7 channels and modulating neuronal excitability.This study describes altered CREB-dependent activity related transcription, and disrupted synaptic composition as common pathological features in ALS. These aberrations are restored by Apamin and XE991, two K+ channel blockers targeting the SK and Kv7 channels and modulating neuronal excitability.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Multipotent Stem Cell, Cotyledon
SUBMITTER: Chiara guerrera
LAB HEAD: GUERRERA Isa Chuara
PROVIDER: PXD020316 | Pride | 2021-05-11
REPOSITORIES: Pride
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