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SLC15A4 functions as a metabolic guardian of immune cells by controlling mTORC1 and AMPK

ABSTRACT: Solute carrier family 15 member A4 (SLC15A4) is a lysosome-resident amino acid/oligopeptide transporter preferentially expressed in immune cells, and plays critical roles in the pathogenesis of lupus and colitis in murine model. SLC15A4 is required for TLR7/9- or NOD1-mediated inflammatory responses through mTORC1 regulation or transporting NOD1 ligand, TriDAP, respectively. To further understand the mechanisms of SLC15A4’s action in inflammatory responses, we applied proximity-dependent biotin identification experiment (BioID) to SLC15A4, and identified a panel of proteins including mTORC1 and its regulator that associate with and/or are proximate to SLC15A4 in vivo.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Takehiro Suzuki

LAB HEAD: Naoshi Dohmae

PROVIDER: PXD020370 | Pride | 2021-08-11

REPOSITORIES: Pride

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			Action	DRS
	BioID_SLC15A4_1.msf	Msf
	BioID_SLC15A4_1.raw	Raw
	BioID_SLC15A4_2.raw	Raw
	BioID_SLC15A4_3.raw	Raw
	BioID_control1.msf	Msf

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