Proteomics

Dataset Information

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Autophagy-mediated metabolic effects of aspirin


ABSTRACT: Aspirin caused a transient reduction of general protein acetylation in blood leukocytes, accompanied by the induction of autophagy. These effects on global protein acetylation could not be attributed to the mere inhibition of EP300, but most likely through the inhibition of other acetyltransferases. To investigate this possibility, we performed a quantitative label-free enriched acetylome analysis, search-ing for proteins that are deacetylated upon EP300 knockout and/or salicylate treatment.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

DISEASE(S): Colon Cancer

SUBMITTER: Valentin SABATET  

LAB HEAD: Damarys Loew

PROVIDER: PXD020556 | Pride | 2021-01-08

REPOSITORIES: Pride

Dataset's files

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Action DRS
Design.xls Xls
H1589FD.msf Msf
H1589FD.raw Raw
H1590FD.msf Msf
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Publications


Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the acetyltransferase activity of EP300. Here, we directly compared the metabolic effects of aspirin medication with those elicited by 48 h fasting in mice, revealing convergent alterations in the plasma and the heart metabolome. Aspirin caused a transient reduction of general protein acetylation in blood leukocytes  ...[more]

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