Proteomics

Dataset Information

0

Proteomics analysis of ligated and recombinant human histones H3 and H4


ABSTRACT: A library of unmodified and differentially modified human histones H3 and H4 was prepared using native chemical ligation as described previously (Bartke et al., 2010; Nakamura et al., 2019). The modification status of histone H3 and H4 products was confirmed by LC-MS/MS.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Andrey Tvardovskiy  

LAB HEAD: Till Bartke

PROVIDER: PXD020773 | Pride | 2023-12-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
H3K27ac.raw Raw
H3K27me2.raw Raw
H3K27me3.raw Raw
H3K4me1.raw Raw
H3K4me1K18acK23acK27me3.raw Raw
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Publications


DNA and histone modifications combine into characteristic patterns that demarcate functional regions of the genome<sup>1,2</sup>. While many 'readers' of individual modifications have been described<sup>3-5</sup>, how chromatin states comprising composite modification signatures, histone variants and internucleosomal linker DNA are interpreted is a major open question. Here we use a multidimensional proteomics strategy to systematically examine the interaction of around 2,000 nuclear proteins wi  ...[more]

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